Carcinoma-associated fibroblasts (CAF) mediate the onset of a proinvasive tumour
microenvironment. The proinflammatory cytokine LIF reprograms fibroblasts into a proinvasive …

10.7554/eLife.13926.001 LINE-1 (L1) retrotransposons represent approximately one sixth
of the human genome, but only the human-specific L1HS-Ta subfamily acts as an …

The study of the proteins that bind to telomeric DNA in mammals has provided a deep
understanding of the mechanisms involved in chromosome-end protection. However, very little is …

L1 retrotransposons are transposable elements and major contributors of genetic variation
in humans. Where L1 integrates into the genome can directly impact human evolution and …

The low-density lipoprotein receptor-related protein LRP1 is a cell surface receptor with
functions in diverse physiological pathways, including lipid metabolism. Here we show that LRP1…

From genetic and biochemical evidence, we previously proposed that S15 inhibits its own
translation by binding to its mRNA in a region overlapping the ribosome loading site. This …

Retrotransposons account for almost half of our genome. They are mobile genetics elements—also
known as jumping genes—but only the L1HS subfamily of Long Interspersed …

Despite a vast expansion in the availability of epigenomic data, our knowledge of the chromatin
landscape at interspersed repeats remains highly limited by difficulties in mapping short-…

Escherichia coli ribosomal protein S15 down regulates its own synthesis by binding to its
mRNA in a region overlapping the ribosome binding site, called the translational operator. This …

Breast cancer is the most prevalent type of cancer in women worldwide. Within breast
tumors, the basal-like subtype has the worst prognosis, prompting the need for new tools to …