By formalizing the relationship between genotype or phenotype and fitness, fitness landscapes
harbor information on molecular and evolutionary constraints. The shape of the fitness …

Speciation is a fundamental evolutionary process, the knowledge of which is crucial for
understanding the origins of biodiversity. Genomic approaches are an increasingly important …

Epistasis occurs when the effect of a mutation depends on its carrier's genetic background.
Despite increasing evidence that epistasis for fitness is common, its role during evolution is …

In the age of next-generation sequencing, the availability of increasing amounts and improved
quality of data at decreasing cost ought to allow for a better understanding of how natural …

How much gene flow is needed to inhibit speciation by the accumulation of Dobzhansky–Muller
incompatibilities (DMIs) in a structured population? Here, we derive these limits in a …

The study of fitness landscapes, which aims at mapping genotypes to fitness, is receiving
ever-increasing attention. Novel experimental approaches combined with next-generation …

The challenge of distinguishing genetic drift from selection remains a central focus of
population genetics. Time-sampled data may provide a powerful tool for distinguishing these …

The role of adaptation in the evolutionary process has been contentious for decades. At the
heart of the century-old debate between neutralists and selectionists lies the distribution of …

Mutations are the source of evolutionary variation. The interactions of multiple mutations can
have important effects on fitness and evolutionary trajectories. We have recently described …

Bacteria generally live in species-rich communities, such as the gut microbiota. Yet little is
known about bacterial evolution in natural ecosystems. Here, we followed the long-term …