Purpose: CDK-activating kinase (CAK) is required for the regulation of the cell cycle and is a
trimeric complex consisting of cyclin-dependent kinase 7 (CDK7), Cyclin H, and the …

Over the last decades, a great body of evidence has defined a novel view of the cellular
mechanism of action of the steroid hormone 17β-estradiol (E2) through its estrogen receptors (ie…

17β-estradiol (E2) regulates diverse physiological effects, including cell proliferation, by
binding to estrogen receptor α (ERα). ERα is both a transcription factor that drives E2-sensitive …

With the advent of omic technologies, our understanding of the molecular mechanisms
underlying estrogen receptor α (ERα)-expressing breast cancer (BC) progression has grown …

Simple Summary Breast cancer (BC) treatment relies on the detection of the estrogen receptor
α (ERα). ERα-expressing BC patients are treated with anti-estrogen drugs (ie, tamoxifen …

17β-estradiol (E2) exerts its physiological effects through the estrogen receptor α (ie, ERα).
The E2:ERα signaling allows the regulation of cell proliferation. Indeed, E2 sustains the …

Dear Editor, Most breast cancers (BC) are estrogen receptor αpositive (ERα+) at diagnosis.
This ERα positivity drives the therapeutic approach for this disease, which often consists of …

The Nuclear Receptor (NR) superfamily of transcription factors comprises 48 members,
several of which have been implicated in breast cancer. Most important is estrogen receptor-α (…

The sex hormone 17β‐estradiol (E2) exerts pleiotropic effects by binding to the ligand‐activated
transcription factor estrogen receptor α (ERα). The E2:ERα complex regulates several …

Most cases of breast cancer (BC) are estrogen receptor α-positive (ERα+) at diagnosis. The
presence of ERα drives the therapeutic approach for this disease, which often consists of …