Resolving the full spectrum of human genome variation using Linked-Reads

…, R Bharadwaj, K Bjornson, C Catalanotti… - Genome …, 2019 - genome.cshlp.org
Large-scale population analyses coupled with advances in technology have demonstrated
that the human genome is more diverse than originally thought. To date, this diversity has …

[HTML][HTML] Fermentation metabolism and its evolution in algae

C Catalanotti, W Yang, MC Posewitz… - Frontiers in plant …, 2013 - frontiersin.org
Fermentation or anoxic metabolism allows unicellular organisms to colonize environments
that become anoxic. Free-living unicellular algae capable of a photoautotrophic lifestyle can …

Multiple facets of anoxic metabolism and hydrogen production in the unicellular green alga Chlamydomonas reinhardtii

AR Grossman, C Catalanotti, W Yang, A Dubini… - New …, 2011 - Wiley Online Library
Many microbes in the soil environment experience micro‐oxic or anoxic conditions for much
of the late afternoon and night, which inhibit or prevent respiratory metabolism. To sustain …

Joint single cell DNA-seq and RNA-seq of gastric cancer cell lines reveals rules of in vitro evolution

N Andor, BT Lau, C Catalanotti, A Sathe… - NAR Genomics and …, 2020 - academic.oup.com
Cancer cell lines are not homogeneous nor are they static in their genetic state and biological
properties. Genetic, transcriptional and phenotypic diversity within cell lines contributes to …

[HTML][HTML] Reverse genetics in Chlamydomonas: a platform for isolating insertional mutants

…, W Pootakham, F Mus, W Yang, C Catalanotti… - Plant Methods, 2011 - Springer
A method was developed to identify insertional mutants of Chlamydomonas reinhardtii
disrupted for selected target genes. The approach relies on the generation of thousands of …

[HTML][HTML] Single-cell sequencing of genomic DNA resolves sub-clonal heterogeneity in a melanoma cell line

…, V Kumar, Y Yin, MG Webb, C Catalanotti… - Communications …, 2020 - nature.com
We performed shallow single-cell sequencing of genomic DNA across 1475 cells from a cell-line,
COLO829, to resolve overall complexity and clonality. This melanoma tumor-line has …

Critical role of Chlamydomonas reinhardtii ferredoxin-5 in maintaining membrane structure and dark metabolism

…, A Dubini, C Catalanotti… - Proceedings of the …, 2015 - National Acad Sciences
Photosynthetic microorganisms typically have multiple isoforms of the electron transfer
protein ferredoxin, although we know little about their exact functions. Surprisingly, a …

A Mutant in the ADH1 Gene of Chlamydomonas reinhardtii Elicits Metabolic Restructuring during Anaerobiosis

L Magneschi, C Catalanotti, V Subramanian… - Plant …, 2012 - academic.oup.com
The green alga Chlamydomonas reinhardtii has numerous genes encoding enzymes that
function in fermentative pathways. Among these, the bifunctional alcohol/acetaldehyde …

Mutagenesis and phenotypic selection as a strategy toward domestication of Chlamydomonas reinhardtii strains for improved performance in photobioreactors

…, C Formighieri, M Mantelli, C Catalanotti… - Photosynthesis …, 2011 - Springer
Microalgae have a valuable potential for biofuels production. As a matter of fact, algae can
produce different molecules with high energy content, including molecular hydrogen (H 2 ) by …

Altered Fermentative Metabolism in Chlamydomonas reinhardtii Mutants Lacking Pyruvate Formate Lyase and Both Pyruvate Formate Lyase and Alcohol …

C Catalanotti, A Dubini, V Subramanian, W Yang… - The Plant …, 2012 - academic.oup.com
Chlamydomonas reinhardtii, a unicellular green alga, often experiences hypoxic/anoxic soil
conditions that activate fermentation metabolism. We isolated three Chlamydomonas …