Apical constriction is a cell shape change that promotes epithelial bending. Activation of
nonmuscle myosin II (Myo-II) by kinases such as Rho-associated kinase (Rok) is important to …

During morphogenesis, contraction of the actomyosin cytoskeleton within individual cells
drives cell shape changes that fold tissues. Coordination of cytoskeletal contractility is …

The propagation of force in epithelial tissues requires that the contractile cytoskeletal machinery
be stably connected between cells through E-cadherin-containing adherens junctions. …

10.7554/eLife.20828.001 Non-muscle cell contractility is critical for tissues to adopt shape
changes. Although, the non-muscle myosin II holoenzyme (myosin) is a molecular motor that …

In epithelial tissues, cells constantly generate and transmit forces between each other. Forces
generated by the actomyosin cytoskeleton regulate tissue shape and structure and also …

The formation of a hollow lumen in a formerly solid mass of cells is a key developmental
process whose dysregulation leads to diseases of the kidney and other organs. Hydrostatic …

Peer review is an important part of the scientific process, but traditional peer review at
journals is coming under increased scrutiny for its inefficiency and lack of transparency. As …

Cryo-electron tomography is the highest resolution tool available for structural analysis of
macromolecular complexes within their native cellular environments. At present, data …

Polarized epithelia define a topological inside and outside, and hence constitute a key
evolutionary innovation that enabled the construction of complex multicellular animal life. Over …

The process of evaluating and negotiating a tenure-track job offer is unstructured and highly
variable, making it susceptible to bias and inequitable outcomes. We outline common …