Objective: Intrahepatic cholangiocarcinoma (ICC) is a rare type of primary liver cancer (PLC)
arising from intrahepatic bile ducts. We carried out a case–control study to assess the …

BACKGROUND/AIMS: The role of coffee in the development of hepatocellular carcinoma (HCC)
is debated. The aim of this study was to investigate the role of coffee in HCC, taking the …

More than 300 different protein post‐translational modifications are currently known, but
only a few have been extensively investigated because modified proteoforms are commonly …

Proteomic surveys with top-down platforms are today revealing thousands of naturally occurring
fragments of bigger proteins. Some of them have not functional meaning because they …

An important contribution to the variability of any proteome is given by the time dimension
that should be carefully considered to define physiological modifications. To this purpose, …

Protein-protein interactions (PPIs) play critical functional and regulatory roles in cellular
processes. They are essential for macromolecular complex formation, which in turn constitutes …

Our aim was to evaluate the role of N‐acetyltransferase (NAT2) and glutathione S‐transferase
M1 and T1 (GSTM1 and GSTT1) polymorphisms in hepatocellular carcinoma (HCC) …

Adamantinomatous craniopharyngioma (ACP) is still often burdened by a poor prognosis in
children as far as the risk of recurrence and the quality of life are concerned. Therefore, …

The combination of top‐down and bottom‐up platforms was utilized for the LC ‐ MS proteomic
characterization of the intracystic fluid of adamantinomatous craniopharyngioma pediatric …

A top-down/bottom-up integrated proteomic approach based on LC-MS and 2-DE analysis
was applied for comparative characterization of medulloblastoma and pilocytic astrocytoma …