The peopling of the Americas has been the subject of extensive genetic, archaeological and
linguistic research; however, central questions remain unresolved 1 , 2 , 3 , 4 , 5 . One …

Characterizing the genetic structure of worldwide populations is important for understanding
human history and is essential to the design and analysis of genetic epidemiological studies…

Since their origin, human populations have colonized the whole planet, but the demographic
processes governing range expansions are mostly unknown. We analyzed the genealogy …

According to evolutionary theory, mitochondria could be poisoned gifts that mothers transmit
to their sons. This is because mutations harmful to males are expected to accumulate in the …

In genetics the ability to accurately describe the familial relationships among a group of
individuals can be very useful. Recent statistical tools succeeded in assessing the degree of …

The pacemaking activity of specialized tissues in the heart and gut results in lifelong rhythmic
contractions. Here we describe a new syndrome characterized by Chronic Atrial and …

Recent work on the Neandertal genome has raised the possibility of admixture between
Neandertals and the expanding population of Homo sapiens who left Africa between 80 and 50 …

Coalescent simulations are widely used to examine the effects of evolution and demographic
history on the genetic makeup of populations. Thanks to recent progress in algorithms and …

Background The developmental and epileptic encephalopathies (DEEs) are the most severe
group of epilepsies which co-present with developmental delay and intellectual disability (…

Objective Resistance to antiseizure medications (ASMs) is one of the major concerns in the
treatment of epilepsy. Despite the increasing number of ASMs available, the proportion of …