Staphylococcus aureus α-toxin is the archetype of bacterial pore forming toxins and a key
virulence factor secreted by the majority of clinical isolates of S. aureus. Toxin monomers bind …

Mitogen activated protein kinase (MAPK) p38 has emerged as a survival protein in cells that
are attacked by bacterial toxins forming small membrane pores. Activation of p38 by pore …

The elucidation of the molecular and immunological mechanisms mediating maintenance of
latency in human tuberculosis aids to develop more effective vaccines and to define …

Pore-forming toxins (PFT) comprise a large, structurally heterogeneous group of bacterial
protein toxins. Nucleated target cells mount complex responses which allow them to survive …

Human papillomavirus type 16 (HPV16) E6 and E7 oncoproteins are required for cellular
transformation and represent candidate targets for HPV-specific and major histocompatibility …

Peptides derived from human tumor antigens have been used in a number of clinical trials to
induce specific immune responses against autologous tumors in cancer patients. Although …

The small β-pore-forming α-toxin, also termed α-hemolysin or Hla is considered to be an
important virulence factor of Staphylococcus aureus. Perforation of the plasma membrane (PM) …

Monitoring of CD8+ T‐cell responses in cancer patients during peptide vaccination is
essential to provide useful surrogate markers and to demonstrate vaccine efficacy. We have …

Staphylococcus aureus is a leading cause of bacterial infections in humans, including life-threatening
diseases such as pneumonia and sepsis. Its small membrane-pore-forming α-…

Human papillomavirus (HPV)-encoded proteins may provide targets for CD8+ or CD4+ T
lymphocytes infiltrating into cervical cancer. We established an MHC class II-restricted CD4+ T …