The purpose of this study was to explore whether there is a linkage between the infiltration
of CD8 + T cells and the risk of death from esophageal cancer. Cases of 70 consecutive …

MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene
copies are commonly found on highly rearranged, extrachromosomal circular DNA (ecDNA). …

Infantile fibrosarcomas are characterized by oncogenic fusions involving neurotrophic
receptor tyrosine kinase genes (NTRK1, NTRK2, and NTRK3), 1 which cause expression of …

The small molecule inhibitor of ataxia telangiectasia and Rad3-related protein (ATR),
elimusertib, is currently being tested clinically in various cancer entities in adults and children. Its …

The small molecule inhibitor of ataxia telangiectasia and Rad3-related protein (ATR),
elimusertib, is currently being tested clinically in various cancer entities in adults and children. Its …

MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene
copies are commonly found on highly rearranged, extrachromosomal circular DNA. The exact …

Extrachromosomal circularization of DNA is an important genomic feature in cancer. However,
the structure, composition and genome-wide frequency of extrachromosomal circular …

In the version of this article initially published, corresponding author Anton G. Henssen was
not displayed as a corresponding author in the HTML version of the article. The error has …

Neuroblastoma cell identity depends on a core regulatory circuit (CRC) of transcription
factors that collaborate with MYCN to drive the oncogenic gene expression program. For …

Background: Repetitive elements make up a large portion of eukaryotic genomes, constituting
two-thirds of human genome. Although their functional importance were recognized as …