Dendritic cell (DC) development begins in the bone marrow but is not completed until after
immature progenitors reach their sites of residence in lymphoid organs. The hematopoietic …

Mice lacking the receptor tyrosine kinase c-Kit (c-Kit W/W ) have hematopoietic defects causing
perinatal death. We have identified a viable c-Kit W/W mouse, termed the "Vickid" mouse. …

Hematopoietic stem cell (HSC) transplantation is limited by histocompatibility barriers and
by lack of space in bone marrow niches. These obstacles prevent in vivo analysis of …

Human erythro-megakaryopoiesis does not occur in humanized mouse models, preventing
the in vivo analysis of human hematopoietic stem cell (HSC) differentiation into these …

Parabiosis experiments demonstrating that dendritic cells (DCs) do not equilibrate between
mice even after prolonged joining by parabiosis have suggested that DCs are derived from …

A prominent feature of sensitizing environmental compounds that cause allergic contact
dermatitis is the rapid induction of an innate inflammatory response that seems to provide …

Osteoclasts are multinucleated giant cells that resorb bone, ensuring development and
continuous remodelling of the skeleton and the bone marrow haematopoietic niche. Defective …

A major obstacle in defining the exact role of extracellular matrix (ECM) in stem cell niches
is the lack of suitable in vitro methods that recapitulate complex ECM microenvironments. …

In-depth analysis of the cellular and molecular mechanisms regulating human HSC function
will require a surrogate host that supports robust maintenance of transplanted human HSCs …

The skin comprises tissue macrophages as the most abundant resident immune cell type.
Their diverse tasks including resistance against invading pathogens, attraction of bypassing …