Depolarizing sodium (Na + ) leak currents carried by the NALCN channel regulate the
resting membrane potential of many neurons to modulate respiration, circadian rhythm, …

Persistently depolarizing sodium (Na + ) leak currents enhance electrical excitability 1 , 2 .
The ion channel responsible for the major background Na + conductance in neurons is the Na …

The sodium leak channel (NALCN) conducts a neuronal background Na+ current that plays
a crucial role in the regulation of breathing, sleep and movement. To perform these vital …

10a Tuesday, February 23, 2021 potential (RMP) of neurons. This Na þ leak current regulates
neuronal excitability underlying processes, such as locomotion and circadian rhythm. …

The sodium leak channel (NALCN) is essential for survival in mammals: NALCN mutations
are life-threatening in humans and knockout is lethal in mice. However, the basic functional …

The compounds slow recovery from inactivated states in a voltage dependent manner by
stabilizing the inactivated-state of the channel. The selective compounds have significantly …

L-type voltage-gated Ca 2+ channels Ca V 1.1 and Ca V 1.2 play a fundamental role in
excitation-contraction coupling in skeletal and cardiac muscle, respectively. These channels …

The “fight-or-flight” response is an evolutionary stress signal that is critical for the survival of
many species. The response involves stimulation of the beta-adrenergic pathway which …

The cannabis plant contains over 120 active constituents, collectively known as phytocannabinoids.
Among these, some cause psychotropic effects, and others do not. The main non-…

… We thank Anna Hermann for excellent technical assistance, Claudia Weidling for
experimental help (Fig. 5C), Dr. Dave Somers (University of Columbus, Ohio, USA) for plasmids …