[HTML][HTML] Long-range regulatory interactions at the 4q25 atrial fibrillation risk locus involve PITX2c and ENPEP
LA Aguirre, ME Alonso, C Badía-Careaga, I Rollán… - BMC biology, 2015 - Springer
Background Recent genome-wide association studies have uncovered genomic loci that
underlie an increased risk for atrial fibrillation, the major cardiac arrhythmia in humans. The …
underlie an increased risk for atrial fibrillation, the major cardiac arrhythmia in humans. The …
[PDF][PDF] Essential roles of cohesin STAG2 in mouse embryonic development and adult tissue homeostasis
Cohesin mediates sister chromatid cohesion and 3D genome folding. Two versions of the
complex carrying STAG1 or STAG2 coexist in somatic vertebrate cells. STAG2 is commonly …
complex carrying STAG1 or STAG2 coexist in somatic vertebrate cells. STAG2 is commonly …
[HTML][HTML] CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart
M Gomez-Velazquez, C Badia-Careaga… - PLoS …, 2017 - journals.plos.org
Cardiac progenitors are specified early in development and progressively differentiate and
mature into fully functional cardiomyocytes. This process is controlled by an extensively …
mature into fully functional cardiomyocytes. This process is controlled by an extensively …
[PDF][PDF] 4D reconstruction of murine developmental trajectories using spherical harmonics
…, M Niksic, A Robert-Moreno, C Badía-Careaga… - Developmental Cell, 2022 - cell.com
Normal organogenesis cannot be recapitulated in vitro for mammalian organs, unlike in species
including Drosophila and zebrafish. Available 3D data in the form of ex vivo images only …
including Drosophila and zebrafish. Available 3D data in the form of ex vivo images only …
A Large Permissive Regulatory Domain Exclusively Controls Tbx3 Expression in the Cardiac Conduction System
…, M Gomez-Velazquez, C Badia-Careaga… - Circulation …, 2014 - Am Heart Assoc
Rationale: The evolutionary conserved Tbx3/Tbx5 gene cluster encodes T-box transcription
factors that play crucial roles in the development and homeostasis of the cardiac conduction …
factors that play crucial roles in the development and homeostasis of the cardiac conduction …
[PDF][PDF] Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF
…, D Gimenez-Llorente, A Cuadrado, C Badia-Careaga… - Cell reports, 2022 - cell.com
The eukaryotic genome is organized in 3D at different scales. This structure is driven and
maintained by different chromatin states and by architectural factors, such as the zinc finger …
maintained by different chromatin states and by architectural factors, such as the zinc finger …
[HTML][HTML] Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics
E Herrero-Galán, I Martínez-Martín… - Redox Biology, 2022 - Elsevier
Titin, as the main protein responsible for the passive stiffness of the sarcomere, plays a key
role in diastolic function and is a determinant factor in the etiology of heart disease. Titin …
role in diastolic function and is a determinant factor in the etiology of heart disease. Titin …
Apical ectodermal ridge morphogenesis in limb development is controlled by Arid3b-mediated regulation of cell movements
JC Casanova, V Uribe, C Badia-Careaga… - …, 2011 - journals.biologists.com
The apical ectodermal ridge (AER) is a specialized epithelium located at the distal edge of
the limb bud that directs outgrowth along the proximodistal axis. Although the molecular basis …
the limb bud that directs outgrowth along the proximodistal axis. Although the molecular basis …
Pluripotency factors regulate the onset of Hox cluster activation in the early embryo
Pluripotent cells are a transient population of the mammalian embryo dependent on
transcription factors, such as OCT4 and NANOG, which maintain pluripotency while suppressing …
transcription factors, such as OCT4 and NANOG, which maintain pluripotency while suppressing …
Nanog regulates Pou3f1 expression at the exit from pluripotency during gastrulation
…, W Jawaid, C Badia-Careaga… - Biology …, 2019 - journals.biologists.com
Pluripotency is regulated by a network of transcription factors that maintain early embryonic
cells in an undifferentiated state while allowing them to proliferate. NANOG is a critical factor …
cells in an undifferentiated state while allowing them to proliferate. NANOG is a critical factor …