Endocytosis is a complex process fulfilling many cellular and developmental functions.
Understanding how it is regulated and integrated with other cellular processes requires a …

During development of multicellular organisms, cells respond to extracellular cues through
nonlinear signal transduction cascades whose principal components have been identified. …

How the shape of embryos and organs emerges during development is a fundamental question
that has fascinated scientists for centuries. Tissue dynamics arise from a small set of cell …

Convergence–extension is a widespread morphogenetic process driven by polarized cell
intercalation. In the Drosophila germ band, epithelial intercalation comprises loss of junctions …

Tissue morphogenesis arises from coordinated changes in cell shape driven by actomyosin
contractions. Patterns of gene expression regionalize cell behaviours by controlling …

Tissue morphogenesis relies on the production of active cellular forces. Understanding how
such forces are mechanically converted into cell shape changes is essential to our …

Key cellular functions and developmental processes rely on cascades of GTPases. GTPases
of the Rab family provide a molecular ID code to the generation, maintenance and transport …

Background Endocytosis allows the import and distribution of cargo into a series of endosomes
with distinct morphological and biochemical characteristics. Our current understanding of …

Adherens junctions display dual properties of robustness and plasticity. In multicellular
organisms, they support both strong cell–cell adhesion and rapid cell–cell contact remodeling …

Morphogenesis relies on the active generation of forces, and the transmission of these forces
to surrounding cells and tissues. Hence measuring forces directly in developing embryos is …