Lysosomal storage diseases (LSDs) often manifest with severe systemic and central nervous
system (CNS) symptoms. The existing treatment options are limited and have no or only …

Background Gaucher Disease is caused by mutations of the GBA gene which encodes the
lysosomal enzyme acid beta-glucosidase (GCase). GBA mutations commonly affect GCase …

Purpose Therapeutic proteins may induce antibodies that inhibit their efficacy or have other
serious biological effects. There is a great need for strategies to predict whether a certain …

The catabolic L-serine (L-threonine) deaminase of Saccharomyces cerevisiae allows the
yeast to grow on media with L-serine or L-threonine as sole nitrogen source. A mutant, cha1 (…

CHA1 of Saccharomyces cerevisiae is the gene for the catabolic L-serine (L-threonine)
dehydratase, which is responsible for biodegradation of serine and threonine. We have …

Gaucher Disease (GD) is caused by mutations of the GBA gene which encodes the lysosomal
enzyme acid beta-glucosidase (GCase). GBA mutations commonly affect GCase function …

Lysosomal diseases often manifest with severe systemic and central nervous system (CNS)
symptoms. The existing treatment options are limited and have no or only modest efficacy …

… of primary and secondary amine boranes. Coordinatively and electronically unsaturated
early … of amine boranes, eg by the Weller group for the case of Rh diphosphine complexes. …

… Surprisingly, to the best of our knowledge, reactions between sulfur dimmides and 'simple'
boranes such as diorganoboron hydrides ('R'2BH') or trialkylborancs (R=3B or R=tBR22) …

… Guido Giffels, Claus Dreisbach, Udo Kragl, Michael Weigerding, Herbert Waldmann, and
Christian Wandrey* … ['] We have now been able to show that reductions of this kind are …