Long-term epigenetic reprogramming of innate immune cells in response to microbes, also
termed "trained immunity," causes prolonged altered cellular functionality to protect from …

Objective— MicroRNAs (miRNA/miR) are stably present in body fluids and are increasingly
explored as disease biomarkers. Here, we investigated influence of impaired wound healing …

Background Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BPD) are
frequently co-occurring and highly heritable mental health conditions. We hypothesized that …

Pyrophosphorylated metabolites of isoprenoid‐biosynthesis (phosphoantigens, PAgs) activate
Vγ9Vδ2 T cells during infections and trigger antitumor activity. This activation depends on …

This study shows that ineffective immune responses not only fail to clear a malignancy, but
can also activate pathways in cancer cells that promote stemness and tumor-seeding capacity…

Emerging evidence shows that microRNAs (miR) are involved in the pathogenesis of a variety
of cancers, including prostate carcinoma (PCa). Little information is available regarding …

Interleukin 12 (IL12) is a key inflammatory cytokine critically influencing Th1/Tc1-T-cell
responses at the time of initial antigen encounter. Therefore, it may be exploited for cancer …

A lack of reliably informative biomarkers to distinguish indolent and lethal prostate cancer is
one reason this disease is overtreated. miR-221 has been suggested as a biomarker in high-…

Despite the obvious clinical significance of post-stroke angiogenesis in aged subjects, a
detailed transcriptomic analysis of post-stroke angiogenesis has not yet been undertaken in an …

The pocket protein (PP) family consists of the three members RB1, p107 and p130 all possessing
tumor suppressive properties. Indeed, the PPs jointly control the G1/S transition mainly …