The sarcoplasmic reticulum Ca 2+ -ATPase, a P-type ATPase, has a critical role in muscle
function and metabolism. Here we present functional studies and three new crystal structures …

The sarcoplasmic (SERCA 1a) Ca2+-ATPase is a membrane protein abundantly present in
skeletal mucles where it functions as an indispensable component of the excitation–…

P-type ATPases extract energy by hydrolysis of adenosine triphosphate (ATP) in two steps,
formation and breakdown of a covalent phosphoenzyme intermediate. This process drives …

Heterogeneous expression of drug target proteins within tumor sites is a major mechanism
of resistance to anticancer therapies. We describe a strategy to selectively inhibit, within …

We present crystal structures of the calcium‐free E2 state of the sarcoplasmic reticulum Ca 2+
‐ATPase, stabilized by the inhibitor thapsigargin and the ATP analog AMPPCP. The …

Calcium (Ca 2+ ) is a fundamental regulator of cell signaling and function. Thapsigargin (Tg)
blocks the sarco/endoplasmic reticulum (ER) Ca 2+ -ATPase (SERCA), disrupts Ca 2+ …

P-type ATPases catalyze the selective active transport of ions like H + , Na + , K + , Ca 2+ ,
Zn 2+ , and Cu 2+ across diverse biological membrane systems. Many members of the P-type …

A synthesis of previous results, which we dub the “standard model,” provides a prediction as
to how isotope fractionation during sulfate reduction should respond to physiological …

The sarco/endoplasmic reticulum Ca 2+ -ATPase (SERCA) is a transmembrane ion
transporter belonging to the P II -type ATPase family. It performs the vital task of re-sequestering …

The structural elucidation of membrane proteins continues to gather pace, but we know little
about their molecular interactions with the lipid environment or how they interact with the …