Monocytic subclones confer resistance to venetoclax-based therapy in patients with acute myeloid leukemia
Identifying characteristics of patients who respond poorly to venetoclax-based therapy and
devising alternative therapeutic strategies for such patients are important topics in AML. We …
devising alternative therapeutic strategies for such patients are important topics in AML. We …
Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy
…, A Koochin, DL Forrest, CA Smith… - Blood, The Journal …, 2008 - ashpublications.org
Familial platelet disorder with propensity to myeloid malignancy (FPD/AML) is an autosomal
dominant syndrome characterized by platelet abnormalities and a predisposition to …
dominant syndrome characterized by platelet abnormalities and a predisposition to …
How established firms respond to threatening technologies
AC Cooper, CG Smith - Academy of Management Perspectives, 1992 - journals.aom.org
… Clayton Smith is assistant professor of management at the University of Notre Dame.
Professor Smith holds the BBA degree from Pace University and the MS and Ph.D degrees from …
Professor Smith holds the BBA degree from Pace University and the MS and Ph.D degrees from …
[PDF][PDF] AMPK/FIS1-mediated mitophagy is required for self-renewal of human AML stem cells
Leukemia stem cells (LSCs) are thought to drive the genesis of acute myeloid leukemia (AML)
as well as relapse following chemotherapy. Because of their unique biology, developing …
as well as relapse following chemotherapy. Because of their unique biology, developing …
World distribution of solar radiation
GOG Löf, JA Duffie, CO Smith - Solar Energy, 1966 - Elsevier
A series of 12 monthly world maps of the daily means of total solar radiation incident on a
horizontal surface has been prepared. Isolines of constant radiation have been drawn at …
horizontal surface has been prepared. Isolines of constant radiation have been drawn at …
[PDF][PDF] Nicotinamide metabolism mediates resistance to venetoclax in relapsed acute myeloid leukemia stem cells
We previously demonstrated that leukemia stem cells (LSCs) in de novo acute myeloid leukemia
(AML) patients are selectively reliant on amino acid metabolism and that treatment with …
(AML) patients are selectively reliant on amino acid metabolism and that treatment with …
Ribozyme-mediated repair of sickle β-globin mRNAs in erythrocyte precursors
Sickle cell anemia is the most common heritable hematological disease, yet no curative
treatment exists for this disorder. Moreover, the intricacies of globin gene expression have made …
treatment exists for this disorder. Moreover, the intricacies of globin gene expression have made …
[HTML][HTML] Targeting acute myeloid leukemia stem cells: a review and principles for the development of clinical trials
DA Pollyea, JA Gutman, L Gore, CA Smith… - …, 2014 - ncbi.nlm.nih.gov
Despite an increasingly rich understanding of its pathogenesis, acute myeloid leukemia
remains a disease with poor outcomes, overwhelmingly due to disease relapse. In recent years, …
remains a disease with poor outcomes, overwhelmingly due to disease relapse. In recent years, …
Intra‐and interreader reproducibility of PI‐RADSv2: A multireader study
Background The Prostate Imaging Reporting and Data System version 2 (PI‐RADSv2) has
been in use since 2015; while interreader reproducibility has been studied, there has been a …
been in use since 2015; while interreader reproducibility has been studied, there has been a …
Venetoclax and azacitidine followed by allogeneic transplant results in excellent outcomes and may improve outcomes versus maintenance therapy among newly …
The combination of venetoclax (ven) and azacitidine (aza) has resulted in high response
rates in the upfront treatment of AML in patients age > 75 and patients unfit for intensive …
rates in the upfront treatment of AML in patients age > 75 and patients unfit for intensive …