Background The ribonuclear protein TDP-43 has been implicated in the pathophysiology of
amyotrophic lateral sclerosis (ALS), with genetic mutations being linked to the neurological …

Three-dimensional (3D) bioprinting is a promising technique for the development of
neuronal in vitro models because it controls the deposition of materials and cells. Finding a …

Human pluripotent stem cells (hPSCs) have generated unprecedented interest in the scientific
community, given their potential applications in regenerative medicine, disease modeling, …

What if we want to investigate something we cannot access in human being and whose
complexity cannot be fully recapitulated by animal models? Easy: WE NEED TO BUILD A NEW …

Background Alterations in the intracellular distribution of TDP-43 were observed in the
skeletal muscles of patients suffering from ALS. However, it is not clear whether these …

BACKGROUND: Nucleic acid testing (NAT) for hepatitis C virus (HCV) and human immunodeficiency
virus (HIV) has been implemented in several European countries and in the United …

Decellularization of blood vessels is a technique to remove cells from the extracellular
matrix (ECM), which can be used as a vascular graft for peripheral or coronary blood vessel …

… ; Schering-Plough, Milan, Italy) at a dose of 3–6 MIU/3 times a week; the remaining 5
patients of group A were treated with rIFN-α (Intron A; Schering-Plough) at a dose of 5–6 MIU/3 …

… rIFN(INTRON A, Schering-Plough, Milan, Italy) at a dose of 3 to 6 million international units
(MUI) three times per week; 4 patients of group A had been treated with rIFN(INTRON A) at a …

CD4 + type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal role in
promoting and maintaining tolerance. The absence of surface markers that uniquely identify …