[PDF][PDF] Multiple early factors anticipate post-acute COVID-19 sequelae
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However,
quantifiable risk factors for PASC and their biological associations are poorly resolved. We …
quantifiable risk factors for PASC and their biological associations are poorly resolved. We …
[PDF][PDF] Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19
We present an integrated analysis of the clinical measurements, immune cells, and plasma
multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …
multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …
Multiomic immunophenotyping of COVID-19 patients reveals early infection trajectories
Host immune responses play central roles in controlling SARS-CoV2 infection, yet remain
incompletely characterized and understood. Here, we present a comprehensive immune …
incompletely characterized and understood. Here, we present a comprehensive immune …
A small sustained increase in NOD1 abundance promotes ligand-independent inflammatory and oncogene transcriptional responses
…, C Hutcheon, NW Lounsbury, CC Rostomily… - Science …, 2020 - science.org
Small, genetically determined differences in transcription [expression quantitative trait loci (eQTLs)]
are implicated in complex diseases through unknown molecular mechanisms. Here, …
are implicated in complex diseases through unknown molecular mechanisms. Here, …
Heterogeneous immunological recovery trajectories revealed in post-acute COVID-19
The immunological picture of how different patients recover from COVID-19, and how those
recovery trajectories are influenced by infection severity, remain unclear. We investigated …
recovery trajectories are influenced by infection severity, remain unclear. We investigated …
A sustained small increase in NOD1 expression promotes ligand-independent oncogenic activity
…, B Dutta, C Hutcheon, NW Lounsbury, CC Rostomily… - bioRxiv, 2019 - biorxiv.org
Small genetically-determined differences in transcription (eQTLs) are implicated in complex
disease but the mechanisms by which small changes in gene expression impact complex …
disease but the mechanisms by which small changes in gene expression impact complex …
Identifying innate immune regulators of Mycobacterium tuberculosis pathogenesis in macrophages
…, E Peterson, AS Akhade, C Rostomily… - The Journal of …, 2021 - journals.aai.org
Tuberculosis (TB) is a leading infectious disease that contributes to approximately 1.4
million deaths annually worldwide. In the present situation of the COVID-19 pandemic and …
million deaths annually worldwide. In the present situation of the COVID-19 pandemic and …
Heterogeneous immunological recovery trajectories revealed in post-acute COVID-19 (preprint)
The immunological picture of how different patients recover from COVID-19, and how those
recovery trajectories are influenced by infection severity, remain unclear. We investigated …
recovery trajectories are influenced by infection severity, remain unclear. We investigated …
A modest change in regulation of NOD1 expression has a major impact on inflammation and gastric cancer
…, AS Akhade, C Hutcheon, C Rostomily… - The Journal of …, 2018 - journals.aai.org
Altered protein dosage by defects in single genes leads to haploinsufficiencies and monogenic
disorders, but the impact of small changes in gene expression on multifactorial disease …
disorders, but the impact of small changes in gene expression on multifactorial disease …
Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories (preprint)
Host immune responses play central roles in controlling SARS-CoV2 infection, yet remain
incompletely characterized and understood. Here, we present a comprehensive immune …
incompletely characterized and understood. Here, we present a comprehensive immune …