User profiles for Clint L. Miller
 | Clint L MillerAssociate Professor, University of Virginia Verified email at virginia.edu Cited by 4371 |
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
Atherosclerosis is the disease process that underlies heart attack and stroke 1 . Advanced
lesions at risk of rupture are characterized by the pathological accumulation of diseased …
lesions at risk of rupture are characterized by the pathological accumulation of diseased …
Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis
In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate,
proliferate and migrate in a process known as phenotypic modulation. However, the phenotype …
proliferate and migrate in a process known as phenotypic modulation. However, the phenotype …
Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk
Coronary artery disease (CAD) is a complex inflammatory disease involving genetic
influences across cell types. Genome-wide association studies have identified over 200 loci …
influences across cell types. Genome-wide association studies have identified over 200 loci …
Genome-wide analysis identifies novel susceptibility loci for myocardial infarction
Aims While most patients with myocardial infarction (MI) have underlying coronary atherosclerosis,
not all patients with coronary artery disease (CAD) develop MI. We sought to address …
not all patients with coronary artery disease (CAD) develop MI. We sought to address …
Role of Ca2+/Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy
CL Miller, M Oikawa, Y Cai, AP Wojtovich… - Circulation …, 2009 - Am Heart Assoc
Rationale: Cyclic nucleotide phosphodiesterases (PDEs) through the degradation of cGMP
play critical roles in maintaining cardiomyocyte homeostasis. Ca 2+ /calmodulin (CaM)-…
play critical roles in maintaining cardiomyocyte homeostasis. Ca 2+ /calmodulin (CaM)-…
Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy
Mitochondria form a complex, interconnected reticulum that is maintained through coordination
among biogenesis, dynamic fission, and fusion and mitophagy, which are initiated in …
among biogenesis, dynamic fission, and fusion and mitophagy, which are initiated in …
[HTML][HTML] Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
Coronary artery disease (CAD) is the leading cause of mortality and morbidity, driven by both
genetic and environmental risk factors. Meta-analyses of genome-wide association studies …
genetic and environmental risk factors. Meta-analyses of genome-wide association studies …
[HTML][HTML] Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation
Genome-wide association studies (GWAS) have identified chromosomal loci that affect risk
of coronary heart disease (CHD) independent of classical risk factors. One such association …
of coronary heart disease (CHD) independent of classical risk factors. One such association …
[HTML][HTML] Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap
…, K Cheng, A Raiesdana, R Kundu, CL Miller… - PLoS …, 2015 - journals.plos.org
Recent genome wide association studies have identified a number of genes that contribute
to the risk for coronary heart disease. One such gene, TCF21, encodes a basic-helix-loop-…
to the risk for coronary heart disease. One such gene, TCF21, encodes a basic-helix-loop-…
Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation
Objective— Genomewide association studies have implicated allelic variation at 9p21.3 in
multiple forms of vascular disease, including atherosclerotic coronary heart disease and …
multiple forms of vascular disease, including atherosclerotic coronary heart disease and …