User profiles for Clotilde Lagier-Tourenne
 | Clotilde Lagier-TourenneMassachusetts General Hospital and Harvard Medical School Verified email at mgh.harvard.edu Cited by 14685 |
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
C Lagier-Tourenne, M Polymenidou… - Human molecular …, 2010 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are
neurodegenerative diseases with clinical and pathological overlap. Landmark discoveries of …
neurodegenerative diseases with clinical and pathological overlap. Landmark discoveries of …
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
We used cross-linking and immunoprecipitation coupled with high-throughput sequencing
to identify binding sites in 6,304 genes as the brain RNA targets for TDP-43, an RNA binding …
to identify binding sites in 6,304 genes as the brain RNA targets for TDP-43, an RNA binding …
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
…, RH Baloh, S Appel, E Simpson, C Lagier-Tourenne… - Science, 2015 - science.org
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective
treatment. We report the results of a moderate-scale sequencing study aimed at increasing the …
treatment. We report the results of a moderate-scale sequencing study aimed at increasing the …
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs
FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved
in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We found that FUS/TLS …
in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We found that FUS/TLS …
[HTML][HTML] Rethinking als: The fus about tdp-43
C Lagier-Tourenne, DW Cleveland - Cell, 2009 - cell.com
Mutations in TDP-43, a DNA/RNA-binding protein, cause an inherited form of the neurodegenerative
disease amyotrophic lateral sclerosis (ALS). Two recent studies (Kwiatkowski et al., …
disease amyotrophic lateral sclerosis (ALS). Two recent studies (Kwiatkowski et al., …
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration
Expanded hexanucleotide repeats in the chromosome 9 open reading frame 72 (C9orf72)
gene are the most common genetic cause of ALS and frontotemporal degeneration (FTD). …
gene are the most common genetic cause of ALS and frontotemporal degeneration (FTD). …
[PDF][PDF] Gain of toxicity from ALS/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC-containing RNAs
Hexanucleotide expansions in C9ORF72 are the most frequent genetic cause of amyotrophic
lateral sclerosis and frontotemporal dementia. Disease mechanisms were evaluated in …
lateral sclerosis and frontotemporal dementia. Disease mechanisms were evaluated in …
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
…, JS Han, C Lagier-Tourenne… - Proceedings of the …, 2010 - National Acad Sciences
Dominant mutations in two functionally related DNA/RNA-binding proteins, trans-activating
response region (TAR) DNA-binding protein with a molecular mass of 43 KDa (TDP-43) and …
response region (TAR) DNA-binding protein with a molecular mass of 43 KDa (TDP-43) and …
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
…, SC Huelga, C Lagier-Tourenne… - Proceedings of the …, 2013 - National Acad Sciences
Transactivating response region DNA binding protein (TDP-43) is the major protein
component of ubiquitinated inclusions found in amyotrophic lateral sclerosis (ALS) and …
component of ubiquitinated inclusions found in amyotrophic lateral sclerosis (ALS) and …
Animal models of neurodegenerative diseases
Animal models of adult-onset neurodegenerative diseases have enhanced the
understanding of the molecular pathogenesis of Alzheimer’s disease, Parkinson’s disease, …
understanding of the molecular pathogenesis of Alzheimer’s disease, Parkinson’s disease, …