What individual differences in neural activity predict the future escalation of alcohol drinking
from casual to compulsive? The neurobiological mechanisms that gate the transition from …

The mesolimbic dopamine system—which originates in the ventral tegmental area and
projects to the striatum—has been shown to be involved in the expression of sex-specific …

Although traditional sensitization paradigms, which result in an augmentation of cocaine-induced
locomotor behavior and dopamine (DA) overflow following repeated experimenter-…

Dopamine modulates medial prefrontal cortex (mPFC) activity to mediate diverse behavioural
functions 1 , 2 ; however, the precise circuit computations remain unknown. One potentially …

Studies investigating the neural mechanisms by which associations between cues and
predicted outcomes control behavior often use associative learning frameworks to understand …

Methods for one-photon fluorescent imaging of calcium dynamics can capture the activity of
hundreds of neurons across large fields of view at a low equipment complexity and cost. In …

A large body of work has aimed to define the precise information encoded by dopaminergic
projections innervating the nucleus accumbens (NAc). Prevailing models are based on …

The ability to associate temporally segregated information and assign positive or negative
valence to environmental cues is paramount for survival. Studies have shown that different …

Alcohol use produces wide-ranging and diverse effects on the central nervous system. It
influences intracellular signaling mechanisms, leading to changes in gene expression, …

Inhibitory interneurons orchestrate prefrontal cortex (PFC) activity, but we have a limited
understanding of the molecular and experience-dependent mechanisms that regulate synaptic …