Alpha-synuclein (αSyn) misfolding is associated with several devastating neurodegenerative
disorders, including Parkinson's disease (PD). In yeast cells and in neurons αSyn …

To better understand the response to mitochondrial dysfunction, we examined the
mechanism by which ATFS-1 (activating transcription factor associated with stress–1) senses …

A variety of debilitating diseases including diabetes, Alzheimer's, Huntington's, Parkinson's,
and prion-based diseases are linked to stress within the endoplasmic reticulum (ER). Using …

The cellular response to unfolded and misfolded proteins in the mitochondrial matrix is poorly
understood. Here, we report on a genome-wide RNAi-based screen for genes that signal …

Mitochondria are required for numerous essential metabolic processes including the regulation
of apoptosis; therefore, proper maintenance of the mitochondrial proteome is crucial. The …

Mitochondrial dysfunction is pervasive in human pathologies such as neurodegeneration,
diabetes, cancer, and pathogen infections as well as during normal aging. Cells sense and …

Genetic analyses previously implicated the matrix-localized protease ClpP in signaling the
stress of protein misfolding in the mitochondrial matrix to activate nuclear-encoded …

Mitochondrial function declines during ageing owing to the accumulation of deleterious
mitochondrial genomes and damage resulting from the localized generation of reactive oxygen …

Deterioration of adult stem cells accounts for much of aging-associated compromised tissue
maintenance. How stem cells maintain metabolic homeostasis remains elusive. Here, we …

Autophagy normally involves the formation of double-membrane autophagosomes that
mediate bulk cytoplasmic and organelle degradation. Here we report the modification of single-…