The fear that schistosomes will become resistant to praziquantel (PZQ) motivates the search
for alternatives to treat schistosomiasis. Recent studies of signaling proteins in …

In spite of the numerous efforts made to control their transmission, parasite schistosomes
still represent a serious public health concern and a major economic problem in many …

Parasitic helminths remain major pathogens of both humans and animals throughout the
world. The success of helminth infections depends on the capacity of the parasite to counteract …

Proteases frequently function not only as individual enzymes but also in cascades or networks.
A notable evolutionary switch occurred in one such protease network that is involved in …

We have identified and characterized a Macrophage Migration Inhibitory Factor (MIF) family
member in the Lophotrochozoan invertebrate, Biomphalaria glabrata, the snail intermediate …

In order to explore the conservation/divergence of transcriptional regulation in the
platyhelminth parasite Schistosoma mansoni, we are studying the structures and functions of …

The epidermal growth factor receptor (EGF-R) plays an important role in development and
cell differentiation, and homologues of EGF-R have been identified in a broad range of …

Evidence supporting the concept that the parasitic trematode Schistosoma mansoni may
escape immune reactions from its vertebrate (man) or invertebrate (the freshwater snail …

The signal transduction protein SmTK4 from Schistosoma mansoni belongs to the family of
Syk kinases. In vertebrates, Syk kinases are known to play specialized roles in signaling …

Insulin signalling is a very ancient and well conserved pathway in metazoan cells, dependent
on insulin receptors (IR) which are transmembrane proteins with tyrosine kinase activity. A …