Introduction Monocytes circulate in the bloodstream for up to 3 to 5 days. Concomitantly,
immunological imprinting of either tolerance (immunosuppression) or trained immunity (innate …

Innate immune memory is the phenomenon whereby innate immune cells such as
monocytes or macrophages undergo functional reprogramming after exposure to microbial …

Introduction Trained immunity refers to the memory characteristics of the innate immune system.
Memory traits of innate immunity have been reported in plants and invertebrates, as well …

Induction of trained immunity (innate immune memory) is mediated by activation of immune
and metabolic pathways that result in epigenetic rewiring of cellular functional programs. …

SWI/SNF is a chromatin remodeling complex that facilitates expression of a number of yeast
genes. Here we demonstrate that SWI/SNF can be recruited from yeast nuclear extracts by a …

Glucocorticoid receptor is a transcription factor that is ubiquitously expressed. Glucocorticoids
are circadian steroids that regulate a wide range of bodily functions, including immunity. …

A novel, quantitative nucleosome array assay has been developed that couples the activity
of a nucleosome ‘remodeling’activity to restriction endonuclease activity. This assay has …

Immunological memory in vertebrates is often exclusively attributed to T and B cell function.
Recently it was proposed that the enhanced and sustained innate immune responses …

The Gene Ontology (GO) knowledgebase ( http://geneontology.org ) is a comprehensive
resource concerning the functions of genes and gene products (proteins and noncoding RNAs). …

The compaction of eukaryotic DNA into chromatin has been implicated in the regulation of
all DNA processes. To unravel the higher-order folding of chromatin, we used magnetic …