In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise
to generate mutations in virtually every protein-coding gene of the mouse genome in a …

Glypicans are a family of heparan sulfate proteoglycans that are linked to the cell surface
through a glycosyl–phosphatidylinositol anchor. One member of this family, glypican-3 (Gpc3), …

Complement-derived anaphylatoxins regulate immune and inflammatory responses through
G-protein-coupled receptor (GPCR)-mediated signalling 1 , 2 , 3 , 4 . C5L2 (also known as …

Rationale: Many authors have suggested that the mechanism by which atelectasis contributes
to injury is through the repetitive opening and closing of distal airways in lung regions that …

Oculodentodigital dysplasia (ODDD) is an autosomal dominant disorder characterized by
pleiotropic developmental anomalies of the limbs, teeth, face and eyes that was shown …

Fanconi anaemia (FA) is an autosomal recessive disease characterized by bone marrow
failure, variable congenital malformations and predisposition to malignancies 1,2 . Cells …

Although next-generation sequencing has revolutionized the ability to associate variants with
human diseases, diagnostic rates and development of new therapies are still limited by a …

The role of sex in biomedical studies has often been overlooked, despite evidence of sexually
dimorphic effects in some biological studies. Here, we used high-throughput phenotype …

Fanconi Anemia (FA) is an autosomal recessive disorder characterized by cellular
hypersensitivity to DNA cross-linking agents. Recent studies suggest that FA proteins share a …

The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel
in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Here we …