Individuals with Down syndrome (DS; trisomy 21) display hyperactivation of interferon (IFN)
signaling and chronic inflammation, which could potentially be explained by the extra copy of …

… Colin Sempeck … Sempeck: Writing–original draft, writing–review and editing, libraries
were designed and formulated. D. Ghosh: Formal analysis, writing–original draft, writing–review …

Microhomology-mediated end joining (MMEJ) is an intrinsically mutagenic pathway of DNA
double-strand break (DSB) repair essential for proliferation of homologous recombination (…

Cytokine storms are drivers of pathology and mortality in myriad viral infections affecting the
human population. In SARS-CoV-2-infected patients, the strength of the cytokine storm has …

Undifferentiated round cell sarcomas, which carry the BCOR-CCNB3 fusion gene, have
traditionally been called “Ewing-like sarcomas” and have been treated with Ewing sarcoma …

Gemcitabine and cisplatin (GC) combination neoadjuvant chemotherapy (NAC) followed by
radical cystectomy (RC) is the standard of care for treating muscle-invasive bladder cancer (…

4091: Functional genomic screening in gemcitabine and cisplatin resistant bladder cancer
cell lines identifies DNA repair pathways as mediators of chemosensitivity | Cancer Research …

Neoadjuvant platinum-based chemotherapy (NAC) followed by radical cystectomy is the
preferred first-line option for treating patients diagnosed with muscle-invasive bladder cancer (…

Mutations in the KRAS oncogene are frequent in lung adenocarcinomas (LUADs).
Unfortunately, KRAS lacks a pharmacologically available inhibitor for precision oncology. …

Cytokine storms are drivers of pathology and mortality in myriad viral infections affecting the
human population. In SARS-CoV-2-infected patients, the strength of the cytokine storm has …