Consistent daylight oscillations and abundant oxygen availability are fundamental to human
health. Here, we investigate the intersection between light-sensing (Period 2 [PER2]) and …

Chronic airway diseases, such as wheezing and asthma, remain significant sources of
morbidity and mortality in the pediatric population. This is especially true for preterm infants who …

Differentiation of human bronchial epithelial cells (HBEs) in air-liquid interface (ALI) cultures
recapitulates organotypic modeling of the in vivo environment. Although ALI cultures are …

Background: Recently, we identified the circadian rhythm protein Period 2 (PER2) in robust
cardioprotection from myocardial ischemia (MI). Based on findings that perioperative MI is …

Exposure to cigarette smoke and e-cigarettes, with nicotine as the active constituent, contributes
to increased health risks associated with asthma. Nicotine exerts its functional activity …

Throughout the evolutionary time, all organisms and species on Earth evolved with an
adaptation to consistent oscillations of sunlight and darkness, now recognized as ‘circadian …

Premature infants are frequently and intermittently administered supplemental oxygen during
hypoxic episodes, resulting in cycles of intermittent hypoxia and hyperoxia. The relatively …

Supplemental O 2 (hyperoxia), necessary for maintenance of oxygenation in premature infants,
contributes to neonatal and pediatric airway diseases including asthma. Airway smooth …

Mouse embryonic stem cells (ESCs) can be transfected by electroporation, liposomal reagents,
and viral transduction methods. The cationic polymer polyethylenimine (PEI) has been …

Supplemental O 2 remains a necessary intervention for many premature infants (<34 wk
gestation). Even moderate hyperoxia (<60% O 2 ) poses a risk for subsequent airway disease, …