Massively multiplexed affinity characterization of therapeutic antibodies against SARS-CoV-2 variants

…, R Lopez, R Emerson, C Lin, C Shikany… - Antibody …, 2022 - academic.oup.com
Antibody therapies represent a valuable tool to reduce COVID-19 deaths and hospitalizations.
Multiple antibody candidates have been granted emergency use authorization by the …

Neuron-astrocyte networking: astrocytes orchestrate and respond to changes in neuronal network activity across brain states and behaviors

MR Van Horn, NJ Benfey, C Shikany… - Journal of …, 2021 - journals.physiology.org
Astrocytes are known to play many important roles in brain function. However, research
underscoring the extent to which astrocytes modulate neuronal activity is still underway. Here we …

High-throughput ML-guided design of diverse single-domain antibodies against SARS-CoV-2

…, R Emerson, B Alipanahi, C Lin, C Shikany… - bioRxiv, 2023 - biorxiv.org
Treating rapidly evolving pathogenic diseases such as COVID-19 requires a therapeutic
approach that accommodates the emergence of viral variants over time. Our machine learning (…

Selective IL-21 and IFN-alpha immunocytokines engineered using the AlphaSeq platform

C Lin, C Shikany, L Homad, J Fint, R Bansal… - Cancer Research, 2024 - AACR
Although cytokine therapies have demonstrated curative effects in some cancer patients,
clinical use remains limited due to undesired toxicity profiles accompanying systemic …

High-throughput ML-guided design of diverse single-domain antibodies against SARS-CoV-2 (preprint)

…, R Emerson, B Alipanahi, C Lin, C Shikany… - 2023 - pesquisa.bvsalud.org
Treating rapidly evolving pathogenic diseases such as COVID-19 requires a therapeutic
approach that accommodates the emergence of viral variants over time. Our machine learning (…

Massively Multiplexed Affinity Characterization of Therapeutic Antibodies Against SARS-CoV-2 Variants (preprint)

E Engelhart, R Lopez, R Emerson, C Lin, C Shikany… - 2021 - pesquisa.bvsalud.org
Antibody therapies represent a valuable tool to reduce COVID-19 deaths and hospitalizations.
Multiple antibody candidates have been granted emergency use authorization by the FDA …

[PDF][PDF] Good News

F Blaney - People, 1992 - crossworks.holycross.edu
… Alfred Shikany Joe & Colleen Shikany Joseph & Joyce Shikany Suzanne Shikany Larry
Tanber Mary Wendt Carl, Nora & Paul Werner M/M John Wienke Bill & Lil Yeater …

[HTML][HTML] Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

…, JI Rotter, PJ Schreiner, J Shikany… - Nature …, 2019 - nature.com
Both short and long sleep are associated with an adverse lipid profile, likely through different
biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we …

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

…, BL Salako, PJ Schreiner, JM Shikany… - Molecular …, 2021 - nature.com
Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low
SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, …

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep …

…, T Roenneberg, JI Rotter, PJ Schreiner, J Shikany… - bioRxiv, 2019 - biorxiv.org
Both short and long sleep are associated with an adverse lipid profile, likely through different
biological pathways. To provide new insights in the biology of sleep-associated adverse …