Many natural underwater adhesives harness hierarchically assembled amyloid
nanostructures to achieve strong and robust interfacial adhesion under dynamic and turbulent …

The relatively flat energy landscapes associated with intrinsically disordered proteins makes
modeling these systems especially problematic. A comprehensive model for these proteins …

Doublecortin (Dcx) defines a growing family of microtubule (MT)-associated proteins (MAPs)
involved in neuronal migration and process outgrowth. We show that Dcx is essential for the …

N-linked glycosylation modulates protein folding and stability through a variety of mechanisms.
As such there is considerable interest in the development of general rules to predict the …

The characterization of intrinsically disordered proteins is challenging because accurate
models of these systems require a description of both their thermally accessible conformers and …

Given that α-synuclein has been implicated in the pathogenesis of several neurodegenerative
disorders, deciphering the structure of this protein is of particular importance. While …

α-Synuclein, a protein that forms ordered aggregates in the brains of patients with Parkinson’s
disease, is intrinsically disordered in the monomeric state. Several studies, however, …

A new method has been developed to compute the probability that each amino acid in a
protein sequence is in a particular secondary structural element. Each of these probabilities is …

Amyloid-β is an intrinsically disordered protein that forms fibrils in the brains of patients with
Alzheimer’s disease. To explore factors that affect the process of fibril growth, we computed …

The accurate assessment of a patient’s risk of adverse events remains a mainstay of clinical
care. Commonly used risk metrics have been based on logistic regression models that …