We have identified previously a repressor element in the transcription start site region of the
cyclin E1 promoter that periodically associates with an atypical, high molecular weight E2F …

p53 is regulated by multiple posttranslational modifications, including Hdm2-mediated
ubiquitylation that drives its proteasomal degradation. Here, we identify the p53-associated factor …

To better understand intranuclear-targeting mechanisms, we have studied the transport of
U3 snoRNA in human cells. Surprisingly, we found that PHAX, the snRNA export adaptor, is …

Primary cilia (PC) are important signaling hubs, and we here explored their role in colonic
pathology. In the colon, PC are mostly present on fibroblasts, and exposure of mice to either …

The R2TP chaperone cooperates with HSP90 to integrate newly synthesized proteins into
multi-subunit complexes, yet its role in tissue homeostasis is unknown. Here, we generated …

To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer (CRC), we
generated mice deficient for cyclin A2 in colonic epithelial cells (CECs). Colons of these mice …

Transport of C/D snoRNPs to nucleoli involves nuclear export factors. In particular, CRM1
binds nascent snoRNPs, but its precise role remains unknown. We show here that both CRM1 …

The progression of human immunodeficiency virus (HIV) is associated with mucosal damage
in the gastrointestinal (GI) tract. This damage enables bacterial translocation from the gut …

Suppressors of cytokine signalling (SOCS) represent a newly discovered family of molecules
that seem to play an important role in the shutting off of cytokine and possibly peptide …

The retinoblastoma protein pRB is involved in the transcriptional control of genes essential
for cell cycle progression and differentiation. pRB interacts with different transcription factors …