[HTML][HTML] CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020

C D'Angelo, A Casillo, C Melchiorre, C Lauro… - Marine Drugs, 2022 - mdpi.com
The development of new approaches to prevent microbial surface adhesion and biofilm
formation is an emerging need following the growing understanding of the impact of biofilm-…

[HTML][HTML] Development of high-copy number plasmids in Pseudoalteromonas haloplanktis TAC125

M Calvanese, C Balestra, A Colarusso, C Lauro… - Applied Microbiology …, 2023 - Springer
The Antarctic bacterium Pseudoalteromonas haloplanktis TAC125 (PhTAC125) is considered
an interesting alternative host for the recombinant protein production, that can be explored …

[HTML][HTML] Recombinant protein production in Pseudoalteromonas haloplanktis TAC125 biofilm

M Calvanese, C D'Angelo, C Lauro, ML Tutino… - Biofilm, 2024 - Elsevier
Biofilms have great potential for producing valuable products, and recent research has been
performed on biofilms for the production of compounds with biotechnological and industrial …

Cold-adapted bacterial extracts as a source of anti-infective and antimicrobial compounds against Staphylococcus aureus

M Artini, R Papa, G Vrenna, C Lauro… - Future …, 2019 - Future Medicine
Aim: The dramatic emergence of antibiotic resistance has directed the interest of research
toward the discovery of novel antimicrobial molecules. In this context, cold-adapted marine …

[HTML][HTML] Improvement of Pseudoalteromonas haloplanktis TAC125 as a Cell Factory: IPTG-Inducible Plasmid Construction and Strain Engineering

A Colarusso, C Lauro, M Calvanese, E Parrilli… - Microorganisms, 2020 - mdpi.com
Our group has used the marine bacterium Pseudoalteromonas haloplanktis TAC125 (PhTAC125)
as a platform for the successful recombinant production of “difficult” proteins, including …

[HTML][HTML] Conditional gene silencing in the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125

C Lauro, A Colarusso, M Calvanese, E Parrilli… - Research in …, 2022 - Elsevier
Since the release in 2005 of the genome sequence and annotation of the first Antarctic marine
bacterium, the number of genomes of psychrophilic microorganisms in public databases …

[HTML][HTML] Active human full-length CDKL5 produced in the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125

A Colarusso, C Lauro, M Calvanese, E Parrilli… - Microbial Cell …, 2022 - Springer
Background A significant fraction of the human proteome is still inaccessible to in vitro studies
since the recombinant production of several proteins failed in conventional cell factories. …

[HTML][HTML] Modelling hCDKL5 heterologous expression in bacteria

…, V Ghini, M Calvanese, A Colarusso, C Lauro… - Metabolites, 2021 - mdpi.com
hCDKL5 refers to the human cyclin-dependent kinase like 5 that is primarily expressed in the
brain. Mutations in its coding sequence are often causative of hCDKL5 deficiency disorder, …

Soluble Recombinant Protein Production in Pseudoalteromonas haloplanktis TAC125: The Case Study of the Full-Length Human CDKL5 Protein

M Calvanese, A Colarusso, C Lauro, E Parrilli… - … Proteins: Methods and …, 2022 - Springer
The Antarctic bacterium Pseudoalteromonas haloplanktis TAC125 is an unconventional
protein production host displaying a notable proficiency in the soluble production of difficult …

P10. Joining the dots… use of sulforaphane to relieve both BDNF production and NRF2-dependent antioxidant potential in CDKL5 deficiency disease: a case study

A Colarusso, M Calvanese, C Lauro, E Parrilli… - 2019 - elea.unisa.it
Mutations in X-linked CDKL5 gene have been associated to an ultra-rare human disease,
now which affects in majority girls and is almost always associated to early-onset epilepsy and …