The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …

Despite their crucial role in health and disease, our knowledge of immune cells within human
tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 adult …

The cellular landscape of the human intestinal tract is dynamic throughout life, developing
in utero and changing in response to functional requirements and environmental exposures. …

INTRODUCTION The thymus is the critical organ for T cell development and T cell receptor (TCR)
repertoire formation, which shapes the landscape of adaptive immunity. T cell …

Single-cell genomics studies have decoded the immune cell composition of several human
prenatal organs but were limited in describing the developing immune system as a …

Background Combined immunodeficiencies are marked by inborn errors of T-cell immunity
in which the T cells that are present are quantitatively or functionally deficient. Impaired …

Background Studies of monogenic gastrointestinal diseases have revealed molecular pathways
critical to gut homeostasis and enabled the development of targeted therapies. Methods …

Primary immunodeficiency disorders enable identification of genes with crucial roles in the
human immune system. Here we study patients suffering from recurrent bacterial, viral and …

Despite signs of infection, the involvement of the oral cavity in COVID-19 is poorly understood.
To address this, single-cell RNA sequencing data-sets were integrated from human minor …

It is not fully understood why COVID-19 is typically milder in children 1 , 2 – 3 . Here, to examine
the differences between children and adults in their response to SARS-CoV-2 infection, …