[HTML][HTML] Cholic acid protects in vitro neurovascular units against oxygen and glucose deprivation-induced injury through the BDNF-TrkB signaling pathway

C Li, X Wang, J Yan, F Cheng, X Ma, C Chen… - … Medicine and Cellular …, 2020 - hindawi.com
Ischemic stroke (IS) can disrupt various types of brain cells in the neurovascular unit (NVU)
at both the structural and functional levels. Therefore, NVU is considered to be a more …

Exploring the pharmacological mechanism of calculus bovis in cerebral ischaemic stroke using a network pharmacology approach

X Du, C Li, S Zhang, C Sun, X Zhang, C Chen… - Journal of …, 2022 - Elsevier
Congai Chen: Methodology, Formal analysis, implemented the methds and conducted
the analysis. All authors read and approved the final manuscript. Xueqian Wang: Writing – …

[HTML][HTML] Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer's disease

W Xu, B Ren, Z Zhang, C Chen, T Xu, S Liu… - Frontiers in …, 2022 - frontiersin.org
There is yet no effective drug for Alzheimer’s disease (AD) which is one of the world’s most
common neurodegenerative diseases. The Qin-Zhi-Zhu-Dan Formula (QZZD) is derived from …

[HTML][HTML] Toxicological safety evaluation of Qin-Zhi-Zhu-Dan formula in rats during the treatment and recovery periods

W Xu, D Chen, Z Zhang, S Liu, C Chen… - Frontiers in …, 2022 - frontiersin.org
Background: Qinzhi Zhudan Formula (QZZD), optimized from Angong Niuhuang Wan, consists
of Radix Scutellariae, Fructus Gardeniae and Pulvis Fellis Suis. We had investigated the …

[HTML][HTML] Refined Qingkailing protects the in vitro neurovascular unit against oxygen–glucose deprivation and re-oxygenation-induced injury

Z Ren, C Chen, Y Zheng, S Zhang, J Yan… - Biomedicine & …, 2023 - Elsevier
Since the proposal of the neurovascular unit (NVU) theory, it has become almost mandatory
for neuroprotective medicines against ischaemic stroke (IS) to focus on this unit. Refined …

[HTML][HTML] Qinzhi Zhudan formula improves memory and alleviates neuroinflammation in vascular dementia rats partly by inhibiting the TNFR1-mediated TNF pathway

S Liu, F Cheng, B Ren, W Xu, C Chen, C Ma… - Journal of Traditional …, 2022 - Elsevier
Objective The Qinzhi Zhudan formula (QZZD) exhibits a prominent therapeutic effect in the
treatment of vascular dementia (VaD). This study combined a network pharmacology …

Causal relationship between psoriasis vulgaris and dementia: Insights from Mendelian randomization analysis

…, Y Zheng, C Chen, X Kang, D Chen… - Experimental …, 2024 - Wiley Online Library
Many clinical studies have demonstrated a correlation between psoriasis vulgaris and
dementia, yet this correlation remains controversial. Our study employed the Mendelian …

Exploring the Pharmacological Mechanism of Bezoar on Cerebral Ischemic Stroke using a Network Pharmacology Approach

X Du, C Li, B Ren, N Deng, C Chen, X Wang, F Cheng… - bioRxiv, 2020 - biorxiv.org
Background Ischemic stroke is a common clinical disease limited by its time window for
treatment. In addition to its high mortality rate, only one treatment currently exists for ischemic …

Multiple detoxification genes confer imidacloprid resistance to Sitobion avenae Fabricius.

…, SX Su Xu, XLF Xie LanFen, ZCA Zhen CongAi… - 2020 - cabidigitallibrary.org
The English grain aphid, Sitobion avenae Fabricius, is one of the major wheat pests distributed
worldwide. Insecticide application is typically effective for controlling S. avenae, However…

The sulfoximine insecticide sulfoxaflor exposure reduces the survival status and disrupts the intestinal metabolism of the honeybee Apis mellifera

S Cheng, P Dai, R Li, Z Chen, P Liang, X Xie… - Journal of Hazardous …, 2023 - Elsevier
Honeybees (Apis mellifera) are indispensable pollinators in agricultural production, biodiversity
conservation, and nutrients provision. The abundance and diversity of honeybees have …