User profiles for Connie Ha

Connie Ha

BD Genomics
Verified email at bd.com
Cited by 4927

[HTML][HTML] Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health

CWY Ha, YY Lam, AJ Holmes - World Journal of Gastroenterology …, 2014 - ncbi.nlm.nih.gov
Gut microbes comprise a high density, biologically active community that lies at the interface
of an animal with its nutritional environment. Consequently their activity profoundly …

[HTML][HTML] Recurrent R-spondin fusions in colon cancer

…, Y Guan, V Janakiraman, BS Jaiswal, J Guillory, C Ha… - Nature, 2012 - nature.com
Identifying and understanding changes in cancer genomes is essential for the development
of targeted therapeutics 1 . Here we analyse systematically more than 70 pairs of primary …

[HTML][HTML] Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice

YY Lam, CWY Ha, CR Campbell, AJ Mitchell… - PloS one, 2012 - journals.plos.org
We investigated the relationship between gut health, visceral fat dysfunction and metabolic
disorders in diet-induced obesity. C57BL/6J mice were fed control or high saturated fat diet (…

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

…, A Chaudhuri, R Gupta, J Guillory, K Toy, C Ha… - Nature …, 2016 - nature.com
We analyzed transcriptomes (n = 211), whole exomes (n = 99) and targeted exomes (n =
103) from 216 malignant pleural mesothelioma (MPM) tumors. Using RNA-seq data, we …

The mutation spectrum revealed by paired genome sequences from a lung cancer patient

…, J Stinson, P Yue, Y Zhang, KP Pant, D Bhatt, C Ha… - Nature, 2010 - nature.com
Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small-cell
lung carcinomas in smokers being the predominant form of the disease 1 , 2 . Although …

[HTML][HTML] A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models

…, T Earr, K Gadkar, T Giese, A Gill, J Gnörich, C Ha… - Nature …, 2023 - nature.com
Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease
(AD), suggesting that activation of this innate immune receptor may be a useful therapeutic …

[PDF][PDF] Translocation of viable gut microbiota to mesenteric adipose drives formation of creeping fat in humans

CWY Ha, A Martin, GD Sepich-Poore, B Shi, Y Wang… - Cell, 2020 - cell.com
A mysterious feature of Crohn's disease (CD) is the extra-intestinal manifestation of "creeping
fat" (CrF), defined as expansion of mesenteric adipose tissue around the inflamed and …

Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes

…, M Jackson, S Peńa-Llopis, J Guillory, K Toy, C Ha… - Nature …, 2015 - nature.com
To further understand the molecular distinctions between kidney cancer subtypes, we analyzed
exome, transcriptome and copy number alteration data from 167 primary human tumors …

Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis

…, P Caplazi, SE Kauder, S Biswas, SK Karnik, C Ha… - Thorax, 2015 - thorax.bmj.com
Background There is microscopic spatial and temporal heterogeneity of pathological changes
in idiopathic pulmonary fibrosis (IPF) lung tissue, which may relate to heterogeneity in …

ERK inhibition overcomes acquired resistance to MEK inhibitors

…, WF Forrest, S Heldens, H Chen, K Toy, C Ha… - Molecular cancer …, 2012 - AACR
The RAS/RAF/MEK pathway is activated in more than 30% of human cancers, most commonly
via mutation in the K-ras oncogene and also via mutations in BRAF. Several allosteric …