Background The undetectable hypnozoite reservoir for relapsing Plasmodium vivax and P.
ovale malarias presents a major challenge for malaria control and elimination in endemic …

Plasmodium falciparum immature gametocytes are not observed in peripheral blood.
However, gametocyte stages in organs such as bone marrow have never been assessed by …

Naturally acquired humoral immunity to the malarial parasite Plasmodium falciparum can
protect against disease, although the precise mechanisms remain unclear. Although antibody …

A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals
carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study …

This study provides evidence that removal of mutant TP53 , thereby deleting its reported
GOF activities, does not impact the survival, proliferation, metastasis, or chemotherapy …

Humoral immune responses require germinal centres (GC) for antibody affinity maturation.
Within GC, B cell proliferation and mutation are segregated from affinity-based positive …

Plasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific.
Naturally acquired antibody responses against multiple P. vivax proteins have been …

Emerging evidence suggests that antibodies against merozoite proteins involved in
Plasmodium falciparum invasion into the red blood cell (RBC) play an important role in clinical …

Background Intermittent preventive treatment in pregnancy has not been evaluated outside
of Africa. Low birthweight (LBW, <2,500 g) is common in Papua New Guinea (PNG) and …

Clinical immunity to P. falciparum malaria is non‐sterilizing, with adults often experiencing
asymptomatic infection. Historically, asymptomatic malaria has been viewed as beneficial and …