User profiles for Connor Whalen

Connor Whalen

University of Washington
Verified email at uw.edu
Cited by 18

[PDF][PDF] SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity

…, Y Li, T Oertel, L Rosado, A Ganesh, C Whalen… - Cell reports, 2021 - cell.com
The need for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) next-generation
vaccines has been highlighted by the rise of variants of concern (VoCs) and the long-term …

[HTML][HTML] Antibacterial effects of low-temperature plasma generated by atmospheric-pressure plasma jet are mediated by reactive oxygen species

…, AN Simmons, A Kazemi, MA Geissel, CT Whalen… - Scientific reports, 2020 - nature.com
Emergence and spread of antibiotic resistance calls for development of non-chemical treatment
options for bacterial infections. Plasma medicine applies low-temperature plasma (LTP) …

Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment

…, HA Pliner, S Tremblay, A Mercer, CJ Whalen… - Nature …, 2022 - nature.com
Aging is accompanied by a host of social and biological changes that correlate with
behavior, cognitive health and susceptibility to neurodegenerative disease. To understand …

Novel vaccine that blunts fentanyl effects and sequesters ultrapotent fentanyl analogues

RC Barrientos, EW Bow, C Whalen… - Molecular …, 2020 - ACS Publications
Active immunization is an emerging potential modality to combat fatal overdose amid the
opioid epidemic. In this study, we described the design, synthesis, formulation, and animal …

Bivalent conjugate vaccine induces dual immunogenic response that attenuates heroin and fentanyl effects in mice

RC Barrientos, C Whalen, OB Torres… - Bioconjugate …, 2021 - ACS Publications
Opioid use disorders and fatal overdose due to consumption of fentanyl-laced heroin remain
a major public health menace in the United States. Vaccination may serve as a promising …

A liquid chromatography high-resolution tandem mass spectrometry method to quantify QS-21 adjuvant and its degradation products in liposomal drug formulations

…, RC Barrientos, OB Torres, S Sweeney, C Whalen… - ACS …, 2023 - ACS Publications
Identification and quantification of an active adjuvant and its degradation product/s in drug
formulations are important to ensure drug product safety and efficacy. QS-21 is a potent …

[HTML][HTML] Concentrations of urinary neopterin, but not suPAR, positively correlate with age in rhesus macaques

…, MM Watowich, N Beeby, C Whalen… - Frontiers in Ecology …, 2022 - frontiersin.org
Identifying biomarkers of age-related changes in immune system functioning that can be
measured non-invasively is a significant step in progressing research on immunosenescence …

Novel chimeric monoclonal antibodies that block fentanyl effects and alter fentanyl biodistribution in mice

B Ban, RC Barrientos, T Oertel, E Komla, C Whalen… - MAbs, 2021 - Taylor & Francis
The prevalence and societal impact of opioid use disorder (OUD) is an acknowledged public
health crisis that is further aggravated by the current pandemic. One of the devastating …

A rapid method for direct quantification of antibody binding-site concentration in serum

EG Abucayon, C Whalen, OB Torres, AJ Duval… - ACS …, 2022 - ACS Publications
The quantitation of the available antibody binding-site concentration of polyclonal antibodies
in serum is critical in defining the efficacy of vaccines against substances of abuse. We …

Enhancing Protective Antibodies against Opioids through Antigen Display on Virus-like Particles

F Shafieichaharberoud, S Lang, C Whalen… - Bioconjugate …, 2023 - ACS Publications
Opioid use disorder (OUD) has become a public health crisis, with recent significant
increases in the number of deaths due to overdose. Vaccination can provide an attractive …