The protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease, is an
obligate intracellular protozoan pathogen. Overlapping mechanisms ensure successful infection…

SIRT2 is a cytoplasmic sirtuin that plays a role in various cellular processes, including
tumorigenesis, metabolism, and inflammation. Since these processes require iron, we …

Human induced pluripotent stem cell (hiPSC) culture has become routine, yet the cost of
pluripotent cell media, frequent medium changes, and the reproducibility of differentiation have …

Hexokinase‐II (HKII) is highly expressed in the heart and can bind to the mitochondrial outer
membrane. Since cardiac hypertrophy is associated with a substrate switch from fatty acid …

Low cardiac output syndrome frequently complicates the post-operative care of infants and
children following cardiac surgery. The onset of low cardiac output follows a predictable …

Many eukaryotic proteins are posttranslationally modified by the esterification of cysteine
thiols to long-chain fatty acids. This modification, protein palmitoylation, is catalyzed by a large …

Protein palmitoylation has diverse effects in regulating protein membrane affinity, localization,
binding partner interactions, turnover and function. Here, we show that palmitoylation also …

We describe a timetable of events during programmed cell death (PCD) in neuronal PC12
cells, specifically, Ras signaling, immediate-early gene (IEG) expression, DNA fragmentation …

While hyperlactatemia in postoperative cardiac surgery patients was once believed to solely
reflect hypoperfusion, either from the accumulated “oxygen debt” during bypass or ongoing …

A cilium is an extension of the cell that contains an axonemal complex of microtubules and
associated proteins bounded by a membrane which is contiguous with the cell body …