Type 2 diabetes mellitus results from the interaction of environmental factors with a combination
of genetic variants, most of which were hitherto unknown. A systematic search for these …

Type 1 diabetes or insulin-dependent diabetes mellitus (IDDM) is due to autoimmune destruction
of pancreatic β-cells. Genetic susceptibility to IDDM is encoded by several loci, one of …

We analyzed genome-wide association data from 1,380 Europeans with early-onset and
morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers …

Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as ‘reduced (or …

Type 1 diabetes (T1D) in children results from autoimmune destruction of pancreatic beta
cells, leading to insufficient production of insulin 1 . A number of genetic determinants of T1D …

Genome-wide association studies have identified common variants that only partially explain
the genetic risk for type 2 diabetes (T2D). Using genome-wide association data from 1,376 …

Background/Aims: On behalf of the Drug and Therapeutics, and Ethics Committees of the
Pediatric Endocrine Society, we sought to update the guidelines published in 2003 on the use …

The mouse igf2 gene, coding for the insulin–like growth factor II (IGF–II) is parentally
imprinted, only the gene copy derived from the father is expressed. To know whether IGF2, the …

Insulin from the β-cells of the pancreatic islets of Langerhans controls energy homeostasis
in vertebrates, and its deficiency causes diabetes mellitus. During embryonic development, …

Diabetes impacts approximately 200 million people worldwide, of whom approximately 10%
are affected by type 1 diabetes (T1D). The application of genome-wide association studies (…