Key points Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells are required to
eliminate cancer cells. We analysed the Ca 2+ dependence of CTL and NK cell cytotoxicity and …

… time-consuming work was done in close collaboration with the technicians Cora Hoxha and
… This article was first published as a preprint: Friedmann KS, Knörck A, Cappello S, Hoxha C, …

Cytotoxic T lymphocytes (CTL) eliminate pathogen-infected and cancerous cells mainly by
polarized secretion of lytic granules (LG, containing cytotoxic molecules like perforin and …

A systematic understanding of different factors influencing cell type specific microRNA
profiles is essential for state-of-the art biomarker research. We carried out a comprehensive …

CTL and NK cells recognize and eliminate cancer cells. However, immune evasion, down
regulation of immune function by the tumor microenvironment, or resistance of cancer cells are …

CTL and NK cells recognize and eliminate cancer cells. However, immune evasion, down
regulation of immune function by the tumor microenvironment, or resistance of cancer cells are …

Cytotoxic CD8 + T lymphocytes (CTL) eliminate infected cells or transformed tumor cells by
releasing perforin-containing cytotoxic granules at the immunological synapse. The secretion …

Melanoma is the deadliest skin cancer with an increasing incidence in the past decades.
The reactive oxygen species (ROS) and dysregulation of signaling pathways play important …

… We thank the Institute for Clinical Hemostaseology and Transfusion Medicine for providing
donor blood; Carmen Hässig and Cora Hoxha for excellent technical help. We thank Jens …

Visualization cell interaction with the extracellular matrix (ECM) mesh works plays a central
role in understanding cell behavior and the corresponding regulatory mechanisms by the …