The maturation of HIV-1 viral particles is essential for viral infectivity. During maturation, many
copies of the capsid protein (CA) self-assemble into a capsid shell to enclose the viral RNA…

The ability to traverse an intact nuclear envelope and productively infect nondividing cells is
a salient feature of human immunodeficiency virus type 1 (HIV-1) and other lentiviruses, but …

10.7554/eLife.16269.001 TRIM5 proteins are restriction factors that block retroviral infections
by binding viral capsids and preventing reverse transcription. Capsid recognition is …

The RNA genome of retroviruses is encased within a protein capsid. To gather insight into
the assembly and function of this capsid, we used electron cryotomography to image human …

To better characterize the assembly of the HIV-1 core, we have used electron cryotomography
(ECT) to image infected cells and the viral particles cryopreserved next to them. We …

Materials and methods. A total of 123 patients (55 female and 68 male; age range, 1 month
to 8 years; mean and median ages, 2.4 and 1.5 years, respectively), who presented with KS …

Background: A 32-base pair (bp) deletion mutation in the betachemokine receptor CCR5
gene has been associated with resistance against human immunodeficiency virus type 1 (HIV-1…

Burkholderia pseudomallei (Bp) and Burkholderia mallei (Bm) cause the often-lethal infectious
diseases melioidosis and glanders, respectively. Curiously, closely related species within …

The vault complex is the largest cellular ribonucleoprotein complex ever characterized and
is present across diverse Eukarya. Despite significant information regarding the structure, …

The ability to traverse an intact nuclear envelope and productively infect non-dividing cells is
a salient feature of human immunodeficiency virus type 1 (HIV-1) and other lentiviruses, but …