Complex human traits are influenced by variation in regulatory DNA through mechanisms
that are not fully understood. Because regulatory elements are conserved between humans …

The second-generation antipsychotic olanzapine is effective in reducing psychotic symptoms
but can cause extreme weight gain in human patients. We investigated the role of the gut …

Environmental factors can promote phenotypic variation through alterations in the epigenome
and facilitate adaptation of an organism to the environment. Although hydrogen sulfide is …

Revealing the mechanisms underlying the reversible physiology of hibernation could have
applications to both human and animal health as hibernation is often associated with disease-…

The notorious plasticity of gene expression responses and the complexity of environmental
gradients complicate the identification of adaptive differences in gene regulation among …

Genome-wide association studies (GWAS) for schizophrenia have identified over 100 loci
encoding> 500 genes. It is unclear whether any of these genes, other than dopamine receptor …

Pharmacogenomics is yet to fulfill its promise of manifestly altering clinical medicine. As one
example, a predictive test for tardive dyskinesia (TD)(an adverse drug reaction consequent …

Haloperidol is an efficacious antipsychotic drug that has serious, unpredictable motor side
effects that limit its utility and cause noncompliance in many patients. Using a drug–placebo …

Tardive dyskinesia (TD) is a debilitating, unpredictable, and often irreversible side effect
resulting from chronic treatment with typical antipsychotic agents such as haloperidol. TD is …

Bipolar disorder (BIP) is a highly heritable disorder with complex patterns of genetic inheritance,
and recent genetic findings highlight the role of numerous common variants each with …