[PDF][PDF] Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular …

…, G van Mierlo, A Einhaus, JL Mary, C Stucki… - The American Journal of …, 2021 - cell.com
Age-related macular degeneration (AMD) is the principal cause of blindness in the elderly
population. A strong effect on AMD risk has been reported for genetic variants at the CFH locus…

[HTML][HTML] Sodium iodate-induced degeneration results in local complement changes and inflammatory processes in murine retina

…, J Biber, AMQ Pousa, N Schäfer, C Stucki… - International journal of …, 2021 - mdpi.com
Age-related macular degeneration (AMD), one of the leading causes of blindness worldwide,
causes personal suffering and high socioeconomic costs. While there has been progress …

[HTML][HTML] N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell …

…, B Elsässer, P Goettig, V Kueppers, F Delobel, C Stucki… - Matrix Biology, 2018 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
the elderly population. Variants in the HTRA1-ARMS2 locus have been linked to increased …

Pharmacological control of platelet-leukocyte interactions by the human anti-P-selectin antibody inclacumab–preclinical and clinical studies

D Kling, C Stucki, S Kronenberg, D Tuerck… - Thrombosis …, 2013 - Elsevier
BACKGROUND AND OBJECTIVE: Elevated levels of platelet-leukocyte aggregates (PLAs)
have been reported in several cardiovascular diseases and suggested to contribute to …

[HTML][HTML] HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication

…, E Melo, D Roth, A Topp, F Delobel, C Stucki… - Scientific reports, 2017 - nature.com
The human protease family HtrA is responsible for preventing protein misfolding and
mislocalization, and a key player in several cellular processes. Among these, HtrA1 is implicated in …

[HTML][HTML] HtrA1 mediated intracellular effects on tubulin using a polarized RPE disease model

…, L Badi, N Flint, ZE Ghiani, F Delobel, C Stucki… - …, 2018 - thelancet.com
Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss.
The protein HtrA1 is enriched in retinal pigment epithelial (RPE) cells isolated from AMD …

Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR levels and age-related macular degeneration

…, A Einhaus, JL Mary, C Stucki… - Am J Hum …, 2021 - research.manchester.ac.uk
Age-related macular degeneration (AMD) is the principal cause of blindness in the elderly
population. A strong effect on AMD risk has been reported for genetic variants at the CFH locus…

[PDF][PDF] … Anna E. van Beek, 3, 4, 5, 6 Esther Willems, 7, 8, 9 Judith Zandstra, 3, 4 Gerard van Mierlo, 3 Alfred Einhaus, 2 Jean-Luc Mary, 2 Corinne Stucki, 2 Bjorn Bakker …

I Jongerius, TW Kuijpers, AI den Hollander - 2021 - scholar.archive.org
Age-related macular degeneration (AMD) is the principal cause of blindness in the elderly
population. A strong effect on AMD risk has been reported for genetic variants at the CFH locus…

[PDF][PDF] Pharmacological control of platelet-leukocyte interactions by the human anti-P-selectin antibody inclacumab–preclinical and clinical studies

JC Tardif, J Gaudreault, C Schmitt - 2013 - academia.edu
… Dorothee Kling, Sven Kronenberg, Dietrich Tuerck, Jacques Gaudreault and Christophe
Schmitt as well as Corinne Stucki were Roche employees at the time of study conduct. Drs. Jean…

Characterisation of a chromatographically produced anti-D immunoglobulin product

M Stucki, R Moudry, C Kempf, A Omar… - … of Chromatography B …, 1997 - Elsevier
A chromatographic fractionation method has been developed for the production of a liquid-stable
anti-D immunoglobulin product for intravenous and intramuscular use. An …