Little is known of the molecular basis of normal auditory function. In contrast to the visual or
olfactory senses, in which reasonable amounts of sensory tissue can be gathered, the …

Ototoxicity refers to damage of inner ear structures (ie, the cochlea and vestibule) and their
function (hearing and balance) following exposure to specific in-hospital medications (ie, …

Hair cells in mouse cochlear cultures are selectively labeled by brief exposure to FM1-43, a
styryl dye used to study endocytosis and exocytosis. Real-time confocal microscopy …

Excitable cells use ion channels to tailor their biophysical properties to the functional demands
made upon them 1 . During development, these demands may alter considerably, often …

The most serious side‐effect of the widely used aminoglycoside antibiotics is irreversible
intracellular damage to the auditory and vestibular hair cells of the inner ear. The mechanism of …

Despite recent progress in identifying genes underlying deafness, there are still relatively
few mouse models of specific forms of human deafness. Here we describe the phenotype of …

Developmental changes in electrophysiological membrane properties of mouse cochlear
inner hair cells (IHCs) were studied from just after terminal differentiation up to functional …

The hair bundles of outer hair cells in the mature mouse cochlea possess three distinct cell‐surface
specializations: tip links, horizontal top connectors, and tectorial membrane …

1 The expression of K + currents in mouse outer hair cells (OHCs) was investigated as a
function of developmental age between postnatal day (P) 0 and P26, using whole‐cell patch …

Although the dynamics of cell membranes and associated structures is vital for cell function,
little is known due to lack of suitable methods. We found, using scanning ion conductance …