Pramipexole has been shown to possess neuroprotective properties in vitro that are partly
independent of its dopaminergic agonism. The site of neuroprotective action is still unknown. …

The retinal degeneration Pde6b rd1 (rd) mutation can be a major pitfall in behavioral studies
using tg2576 mice bred on a B6:SJL genetic background, 1 of the most widely used models …

Donepezil is the current standard symptomatic treatment of mild-to-moderate Alzheimer's
disease (AD) patients. It aims to compensate for the deficit in cholinergic neurotransmission by …

There is growing evidence that impaired sensory processing significantly contributes to
cognitive deficits found in schizophrenia. Electroencephalography ( EEG ) has become an …

The cyclic nucleotide cGMP is an important intracellular messenger for synaptic plasticity and
memory function in rodents. Therefore, inhibition of cGMP degrading phosphodiesterases, …

Glycogen synthase kinase (GSK)-3beta is recognized as a ubiquitous multifunctional enzyme
involved in the modulation of many aspects of neuronal function. Inhibitory control of GSK-…

Major depressive disorder (MDD) is a leading cause of morbidity with a lifetime prevalence
of 10%. There is increasing evidence suggesting synaptic dysfunction and impaired integrity …

Pharmacological treatments in laboratory rodents remain a cornerstone of preclinical
psychopharmacological research and drug development. There are numerous ways in which acute …

In mammals, hippocampal and striatal regions are engaged in separable cognitive processes
usually assessed through species-specific paradigms. To reconcile cognitive testing …

Aβ42-lowering nonsteroidal anti-inflammatory drugs (NSAIDs) constitute the founding
members of a new class of γ-secretase modulators that avoid side effects of pan-γ-secretase …