Endothelial cells in vivo form an interface between flowing blood and vascular tissue,
responding to humoral and physical stimuli to secrete relaxing and contracting factors that …

… In this review Cornelis van Breemen, Qian Chen and Ismail Laher summarize experimental
support for the SBB, and discuss data indicating that: (1) contraction is related more to the …

Vascular smooth muscle shows both plasticity and heterogeneity with respect to Ca 2+
signaling. Physiological perturbations in cytoplasmic Ca 2+ concentration ([Ca 2+ ] i ) may take …

Thoracic aortic aneurysm (TAA) is the life-threatening complication of Marfan syndrome (MFS),
a connective tissue disorder caused by mutations in the fibrillin-1 gene. TAA is …

β-Blockers, eg, atenolol, are the cornerstone therapy for thoracic aortic aneurysm (TAA) in
patients with Marfan syndrome; however, continued aortic dilatation has been reported. We …

1 We characterized the mechanisms in vascular smooth muscle cells (VSMCs) that produce
asynchronous, wave‐like Ca 2+ oscillations in response to phenylephrine (PE). Confocal …

Impaired angiogenesis could contribute to the increased incidence of coronary and peripheral
artery disease in diabetic patients. Angiogenesis is initiated by vascular endothelial …

Diabetes is associated with a perturbation of signaling pathways in vascular tissue, which
causes vasomotor dysfunction such as hypertension and accelerated atherosclerosis. In the …

Studies of the molecular basis of insulin resistance have focused on the peroxisome proliferator
activated receptor gamma (PPARγ, γ1 and γ2). The aim of this study was to determine …

The Na + /Ca 2+ exchanger (NCX) is increasingly recognized as a physiological mediator of
Ca 2+ influx and significantly contributes to salt-sensitive hypertension. We recently …