Rearrangements of the mixed lineage leukemia gene MLL are associated with aggressive
lymphoid and myeloid leukemias. The resulting MLL fusion proteins enforce high-level …

Mammalian telomeres consist of TTAGGG repeats organized in nucleosomes and associated
with a six-protein complex known as shelterin, which preserves telomere structure and …

Chromatin regulation through histone modifications plays an essential role in coordinated
expression of multiple genes. Alterations in chromatin induced by histone modifiers and …

Background The family of zinc finger-containing GATA transcription factors plays critical
roles in cell lineage specification during early embryonic development and organ formation. …

The transcription factor GATA6 and the Fgf/Ras/MAPK signaling pathway are essential for
the development of the primitive endoderm (PrE), one of the two lineages derived from the …

The chromosomal breakpoints of t(4;11) translocation of acute lymphoblastic leukemia (ALL)
have been recently identified at molecular level and shown to involve the AF4 (FEL) gene …

Several lines of evidence suggest that the mixed lineage leukemia protein (MLL, ALL-1,
HRX) plays a role in regulating myelomonocytic differentiation. In this study we examined the …

Telomeres, protective nucleoprotein structures located at the ends of eukaryotic chromosomes
and until recently regarded as transcriptionally silent, are now known to be transcribed …

Telomere stabilization is critical for tumorigenesis. A number of tumors and cell lines use a
recombination-based mechanism, alternative lengthening of telomeres (ALT), to maintain …

By differential screening of a cDNA library obtained from a GM-CSF-dependent human
myeloid leukemia cell line (GF-D8), we identified two novel isoforms of the recently described …