Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study

…, A Desai, G de Lima Lopes, P Grivas, CA Painter… - The Lancet, 2020 - thelancet.com
Background Data on patients with COVID-19 who have cancer are lacking. Here we characterise
the outcomes of a cohort of patients with cancer and COVID-19 and identify potential …

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

…, GM Hughes, KC Keough, CA Painter… - Proceedings of the …, 2020 - National Acad Sciences
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the
cause of COVID-19. The main receptor of SARS-CoV-2, angiotensin I converting enzyme 2 …

[PDF][PDF] COVID-19 and cancer: current challenges and perspectives

…, TK Choueiri, S Peters, BI Rini, JL Warner, CA Painter - Cancer cell, 2020 - cell.com
Patients with cancer have been disproportionately affected by the COVID-19 pandemic.
This effect has included the adverse outcomes in patients with cancer who develop COVID-19, …

The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research

CA Painter, E Jain, BN Tomson, M Dunphy… - Nature medicine, 2020 - nature.com
Despite rare cancers accounting for 25% of adult tumors 1 , they are difficult to study due to
the low disease incidence and geographically dispersed patient populations, which has …

Utilization of COVID-19 treatments and clinical outcomes among patients with cancer: a COVID-19 and Cancer Consortium (CCC19) cohort study

…, TK Choueiri, G de Lima Lopes Jr, P Grivas, CA Painter… - Cancer discovery, 2020 - AACR
Evaluating the potential role of COVID-19 treatments in patients with cancer in a large
observational study, there was no statistically significant 30-day all-cause mortality benefit with …

Age-dependent spontaneous coronary arterial thrombosis in transgenic mice that express a stable form of human plasminogen activator inhibitor-1

M Eren, CA Painter, JB Atkinson, PJ Declerck… - Circulation, 2002 - Am Heart Assoc
Background— Plasminogen activator inhibitor-1 (PAI-1) regulates fibrinolysis and has been
reported to be an independent risk factor for ischemic cardiovascular events. This study …

Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2

JA Schoenhard, LH Smith, CA Painter, M Eren… - Journal of molecular and …, 2003 - Elsevier
Circadian variation in plasminogen activator inhibitor-1 (PAI-1) production likely contributes
to increased risk of myocardial infarction and decreased efficacy of thrombolytic therapy …

[HTML][HTML] Tumor necrosis factor α activates the human plasminogen activator inhibitor-1 gene through a distal nuclear factor κB site

B Hou, M Eren, CA Painter, JW Covington… - Journal of Biological …, 2004 - ASBMB
Plasminogen activator inhibitor-1 (PAI-1) is the major inhibitor of plasminogen activation
and likely plays important roles in coronary thrombosis and arteriosclerosis. Tumor necrosis …

Racial disparities in COVID-19 outcomes among black and white patients with cancer

…, TM Wise-Draper, C Park, CA Painter… - JAMA network …, 2022 - jamanetwork.com
Importance Non-Hispanic Black individuals experience a higher burden of COVID-19 than
the general population; hence, there is an urgent need to characterize the unique clinical …

HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism

AI Guce, SE Mortimer, T Yoon, CA Painter… - Nature structural & …, 2013 - nature.com
Mammalian class II major histocompatibility (MHCII) proteins bind peptide antigens in
endosomal compartments of antigen-presenting cells. The nonclassical MHCII protein HLA-DM …