We developed the Genomic Regions Enrichment of Annotations Tool (GREAT) to analyze
the functional significance of cis-regulatory regions identified by localized measurements of …

The comparison of related genomes has emerged as a powerful lens for genome interpretation.
Here we report the sequencing and comparative analysis of 29 eutherian genomes. We …

The evolution of the amniotic egg was one of the great evolutionary innovations in the history
of life, freeing vertebrates from an obligatory connection to water and thus permitting the …

Hundreds of highly conserved distal cis-regulatory elements have been characterized so far
in vertebrate genomes 1 . Many thousands more are predicted on the basis of comparative …

Direct comparisons of human and non-human primate brains can reveal molecular pathways
underlying remarkable specializations of the human brain. However, chimpanzee tissue is …

The evolutionary forces that establish and hone target gene networks of transcription factors
are largely unknown. Transposition of retroelements may play a role, but its global …

At least 5% of the human genome predating the mammalian radiation is thought to have
evolved under purifying selection, yet protein-coding and related untranslated exons occupy at …

Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

Searches for the genetic underpinnings of uniquely human traits have focused on human-specific
divergence in conserved genomic regions, which reflects adaptive modifications of …

The gain, loss, and modification of gene regulatory elements may underlie a substantial
proportion of phenotypic changes on animal lineages. To investigate the gain of regulatory …