Nicotinamide adenine dinucleotide (NAD + ) is modulated by conditions of metabolic stress
and has been reported to decline with aging in preclinical models, but human data are …

Objective Augmenting nicotinamide adenine dinucleotide (NAD + ) availability may protect
skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD + …

Carnosine is a pleiotropic histidine-containing dipeptide synthesized from β-alanine and l-histidine,
with the intact dipeptide and constituent amino acids being available from the diet. …

The current study investigated transcriptional distortion in prostate cancer cells using the
vitamin D receptor (VDR) as a tool to examine how epigenetic events driven by corepressor …

Excessive glucocorticoid exposure has been shown to be deleterious for pancreatic β-cell
function and insulin release. However, glucocorticoids at physiological levels are essential for …

In non-malignant RWPE-1 prostate epithelial cells signaling by the nuclear receptor Vitamin
D Receptor (VDR, NR1I1) induces cell cycle arrest through targets including CDKN1A (…

The loss of anti-proliferative responsiveness in prostate cancer cell lines toward ligands for
vitamin D receptor, retinoic acid receptors/retinoid X receptors and peroxisome proliferator …

Declines in cellular nicotinamide adenine dinucleotide (NAD) contribute to metabolic
dysfunction, increase susceptibility to disease, and occur as a result of pathogenic infection. The …

Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure
suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with evidence for a …

Adrenocortical carcinoma (ACC) is an aggressive malignancy with poor response to
chemotherapy. In this study, we evaluated a potential new treatment target for ACC, focusing on the …